The study of polymer/solvent interaction has been very important in several fields, such as tissue engineering. A whole understanding of the polymer dissolution process and mechanism could improve and optimize fabrication conditions.

It has been reported that the effect of solvent on polymers could determine the final physical and chemical properties for specific applications.

The aim of this article was to describe a kinetic study of the degradation of PLGA in the presence of chloroform.

A viable reaction scheme to explain the degradation of the copolymer was developed based on the monomolecular constant reaction rates generated by a kinetic study. These results could confirm that the use of some organic solvents in the process of nanoparticles of PLGA preparation, among other, produce undesirable